Drug delivery modeling: analyzing model parameters

Images showing vasculature (magenta) reconstructed from tumor imaging data and a graph illustrating the drug dye concentration in the vascular and extra vascular compartment.

Drug delivery of tumor therapies can be modeled via ordinary differential equations (ODE). The delivery depends on different tumor parameters such as tumor and vascular geometry, vascular permeability and transit time. To estimate the parameters I reconstructed the vascular geometry based on fluorescent-microscopy imaging data and analyzed the time dependent dye concentrations in the vascular- and extra vascular compartment. Based on the data I was able to calculate the parameters required for drug delivery modeling.